Intervenção interdisciplinar em crianças obesas e o impacto na saúde e qualidade de vida / Interdisciplinary intervention in obese children and impact on health and quality of life

OBJETIVO: Verificar os efeitos de um programa de intervenção com exercício físico, atividades recreativas e orientação nutricional na qualidade de vida relacionada à saúde de crianças obesas. MÉTODOS: Trata-se de um ensaio clínico controlado. A população inicial do estudo envolveu crianças com idades entre oito e 11 anos e com índice de massa corporal acima de 97 percentil por idade e sexo, conforme os critérios da Organização Mundial de Saúde, totalizando 44 crianças pareadas em sexo e idade, sendo: grupo caso (n = 22) e grupo controle (n = 22). Determinou-se, antes e após 12 semanas de intervenção (três vezes semanais), o índice de massa corporal e a qualidade de vida relacionada à saúde autor-relatada pelo questionário PedsQL. O grupo controle não participou da intervenção. RESULTADOS: Completaram o estudo 32 crianças (16 em cada). O grupo caso apresentou redução significativa do índice de massa corporal (p = 0,001) e melhorou a qualidade de vida nos domínios físico (p = 0,001), emocional (p = 0,014), social (p = 0,004), psicossocial (p = 0,002) e qualidade de vida geral (p = 0,001), o que não foi observado no grupo controle. CONCLUSÃO: O programa foi efetivo na melhora da saúde e da qualidade de vida de crianças obesas.

OBJECTIVE: To verify the effects of an intervention program including physical exercise and recreational activities, as well as nutritional counseling, on the health-related quality of life of obese children. METHODS: This was a controlled clinical trial. The initial study population included children aged eight to 11 years with a body mass index (BMI) > 97th percentile for age and gender, according to the criteria of the World Health Organization, totaling 44 children matched by gender and age, as case (n = 22) and control groups (n = 22). BMI and self-reported health-related quality of life by Pediatric Quality of Life Inventory were measured before and after 12 weeks of intervention (three times weekly). The control group did not participate in the intervention. RESULTS: Thirty-two children completed the study (16 in each group). The case group showed significant reduction in BMI (p = 0.001) and improved quality of life in the physical (p = 0.001), emotional (p = 0.014), social (p = 0.004), and psychosocial (p = 0.002) domains, as well as in overall quality of life (p = 0.001), which was not observed in the control group. CONCLUSION: The program was effective in improving the health and quality of life of obese children.

Interdisciplinary intervention in obese children and impact on health and quality of life.

OBJECTIVE: To verify the effects of an intervention program including physical exercise and recreational activities, as well as nutritional counseling, on the health-related quality of life of obese children. METHODS: This was a controlled clinical trial. The initial study population included children aged eight to 11 years with a body mass index (BMI) > 97th percentile for age and gender, according to the criteria of the World Health Organization, totaling 44 children matched by gender and age, as case (n = 22) and control groups (n = 22). BMI and self-reported health-related quality of life by Pediatric Quality of Life Inventory were measured before and after 12 weeks of intervention (three times weekly). The control group did not participate in the intervention. RESULTS: Thirty-two children completed the study (16 in each group). The case group showed significant reduction in BMI (p = 0.001) and improved quality of life in the physical (p = 0.001), emotional (p = 0.014), social (p = 0.004), and psychosocial (p = 0.002) domains, as well as in overall quality of life (p = 0.001), which was not observed in the control group. CONCLUSION: The program was effective in improving the health and quality of life of obese children.

Bone mass in children and adolescents infected with human immunodeficiency virus.

OBJECTIVE: To describe bone mineral density (BMD) and bone mineral content (BMC) in children and adolescents infected with the human immunodeficiency virus (HIV), and to compare them with data from the National Health and Nutrition Examination Survey IV (NHANES IV). METHOD: The study included 48 children and adolescents (7 to 17 years old) infected with HIV through vertical transmission. BMC and BMD were measured by dual energy absorptiometry X-ray, by calculating z-scores based on data from NHANES IV. The information on clinical and laboratory parameters of infection by HIV was obtained from medical records. Physical activity, calcium intake, and skeletal maturation were also assessed. Descriptive and inferential statistical procedures were used, with levels of significance set at 5%. RESULTS: Seropositive patients presented lower values compared to data from NHANES IV in all z-scores of bone mass (mean=-0.52 to -1.22, SD=0.91 and 0.84, respectively). Based on the subtotal z-BMD, there was a prevalence of 16.7% of children and adolescents with low bone mass for age. Individuals using protease inhibitors presented a lower total z-BMD when compared to the group that did not use (-1.31 vs. -0.79, p=0.02). There were no bone mass differences in relation to physical activity and calcium intake. CONCLUSIONS: In the present sample children and adolescents living with HIV have low bone mass for age, and the use of protease inhibitors appears to be related to such decreases.

Massa óssea em crianças e adolescentes que vivem com vírus da imunodeficiência humana / Bone mass in children and adolescents infected with human immunodeficiency virus

OBJETIVO: Descrever a densidade mineral óssea (DMO) e conteúdo mineral ósseo (CMO) de crianças e adolescentes que vivem com o vírus da imunodeficiência humana e comparar com os dados do National Health and Nutrition Examination Survey IV (NHANES IV). MÉTODO: Participaram do estudo48 crianças e adolescentes (sete a 17 anos de idade) com infecção pelo vírus da imunodeficiência humana adquirida por transmissão vertical. A DMO e o CMO foram mensurados pela absorciometria por dupla emissão de raios-X, calculando-se escores-z com base nos dados do NHANES IV. Nos prontuários médicos foram obtidas as informações dos parâmetros clínicos e laboratoriais da infecção pelo vírus da imunodeficiência humana. Foram ainda avaliada a atividade física, a ingestão de cálcio e a maturação esquelética. Utilizaram-se procedimentos da estatística descritiva e inferencial, estabelecendo níveis de significância de 5%. RESULTADOS :Os pacientes soropositivos demonstraram valores inferiores comparados aos dados do NHANES IV em todos os escores-z da massa óssea (média = -0,52 a -1,22, dp = 0,91 e 0,84, respectivamente). Com base no z-DMOsubtotal, há uma prevalência de 16,7% de crianças e adolescentes com massa óssea reduzida para a idade. Indivíduos que utilizaram inibidores de protease apresentaram um z-DMOtotal inferior, comparado ao grupo que não utilizou (-1,31 vs. -0,79; p = 0,02). Não foram encontradas diferenças na massa óssea em relação ao nível de atividade física e ingestão de cálcio. CONCLUSÕES: Na presente amostra, crianças e adolescentes que vivem com o vírus da imuno deficiência humana possuem baixa massa óssea para idade, e o uso de inibidores de protease parece estar relacionado a tais reduções.

OBJECTIVE: To describe bone mineral density (BMD) and bone mineral content (BMC) in children and adolescents infected with the human immunodeficiency virus (HIV), and to compare them with data from the National Health and Nutrition Examination Survey IV (NHANES IV). METHOD: The study included 48 children and adolescents (7 to 17 years old) infected with HIV through vertical transmission. BMC and BMD were measured by dual energy absorptiometry X-ray, by calculating z-scores based on data from NHANES IV. The information on clinical and laboratory parameters of infection by HIV was obtained from medical records. Physical activity, calcium intake, and skeletal maturation were also assessed. Descriptive and inferential statistical procedures were used, with levels of significance set at 5%. RESULTS: Seropositive patients presented lower values compared to data from NHANES IV in all z-scores of bone mass (mean = -0.52 to -1.22, SD = 0.91 and 0.84, respectively). Based on the subtotal z-BMD, there was a prevalence of 16.7% of children and adolescents with low bone mass for age. Individuals using protease inhibitors presented a lower total z-BMD when compared to the group that did not use (-1.31 vs. -0.79, p = 0.02). There were no bone mass differences in relation to physical activity and calcium intake. CONCLUSIONS: In the present sample children and adolescents living with HIV have low bone mass for age, and the use of protease inhibitors appears to be related to such decreases.

Cardiovascular prevention in HIV patients: results from a successful intervention program.

OBJECTIVES: To analyze the effect of a prevention program on the estimated cardiovascular risk calculated by three risk scores. METHODS: We prospectively evaluated 87 HIV+patients with elevated cardiovascular risk estimation. Framingham (FRS), PROCAM and National Cholesterol Education Program (ATP-III) were applied. Cardiovascular risk was defined as elevated if >10%. All patients received non-pharmacological (diet, exercise, smoking cessation) and, when appropriate, pharmacological therapy. RESULTS: Mean age was 52 years, 92% were male, 39.1% were smokers, 70.1% had hypertension, 18.4% had diabetes. All patients were under HAART, 56.3% were receiving protease inhibitors (PI). After 6 months, intervention was associated to significant changes on triglycerides (298+/-242 and 206+/-135 mg/dL, p<0.05), total-cholesterol (224+/-47 and 189+/-38 mg/dL, p<0.001), LDL-cholesterol (129+/-44 and 109+/-30 mg/dL, p<0.001). Frequencies of patients with elevated cardiac risk before and 6 months after intervention were 92% x 27.6% (p<0.0001), 80.5% x 50.6% (p<0.0002), and 25.3% x 14.9% (p=0.12), for FRS, ATP III and PROCAM, respectively. CONCLUSIONS: An intervention program focused on reduction of traditional risk factors was able to decrease the frequency of patients with HIV infection and elevated cardiovascular risk estimation. FRS showed greater sensitivity than the other scores.

Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI study.

OBJECTIVES: To compare carotid intima-media thickness (cIMT) of children and adolescents with and without HIV infection and to determine associations among independent socio-demographic, clinical or cardiovascular variables and cIMT in HIV-infected children and adolescents. PATIENTS AND METHODS: This is a matched case-control study comparing 83 HIV-infected and 83 healthy children and adolescents. Clinical and laboratorial parameters, cIMT and echocardiogram were measured. RESULTS: The cIMT was higher in HIV-infected individuals (median 480 microm; interquartile range 463-518 microm) compared with controls (426 microm; range 415-453 microm, P<0.001). In addition, the HIV-infected group showed higher levels of high-sensitive C-reactive protein (medians 1.0 mg/l vs. 0.4 mg/l, P<0.001), glycated hemoglobin (6.1+/-0.9 vs. 5.7+/-0.8%, P=0.028) and triglycerides (medians 0.9 vs. 0.8 mmol/l, P=0.031). Finally, this group showed lower levels of total and high-density lipoprotein-cholesterol. After multivariate analysis, increased cIMT was positively associated with stavudine use [odds ratio (OR): 18.9, P=0.005], left atrial/aorta index (OR: 15.6, P=0.019), suprailiac skinfold (OR: 7.9, P=0.019), tachypnea (OR: 5.9, P=0.031), CD8 lymphocyte count (OR: 5.7, P=0.033) and CD4 T-lymphocyte count (OR: 5.5, P=0.025). cIMT increment was negatively associated with total cholesterol (OR: 0.2, P=0.025) and with CD8 zenith (OR: 0.1, P=0.007). CONCLUSION: In this sample of children and adolescents, having HIV infection was associated with increased cIMT and elevated prevalence of cardiovascular risk factors. These findings suggest that this group should be included in cardiovascular prevention programs.